Working with MELA Sciences, we designed this medical animation to help doctors and their patients …
THE ROLE OF SEROTONIN IN CARCINOID SYNDROME
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admin
In this video, we will discuss tryptophan metabolism as applied to carcinoid syndrome in patients …
APOPTOSIS AND BCL-2
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admin
ABT-199/GDC-0199 is a small molecule drug in co-development by Abbvie and Genentech for the selective inhibition of BCL-2, a key regulator of cellular apoptosis. BCL-2, part of the larger BCL-2 family, is responsible for the sequestration of pro-apoptotic proteins along the mitochondrial membrane. Displacement of these proteins from BCL-2 in cancerous cells may prime these cells for apoptosis.
GLEEVEC (IMATINIB) MOA
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Jordan Maire
Kit is a receptor tyrosine kinase that activates of a number of pathways that direct cell proliferation, survival, and apoptosis. Mutations in Kit that result in constitutive oligomerization in the absence of ligand can drive continuous oncogenic signaling.
ORGANOIDS
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admin
Organoids can be made to resemble organs or tissues such as gut, kidney, pancreas, liver, breast, prostate, and even brain tissue, all complete with accurate micro-anatomy. Due to their amazing ability to self-organize into tissue structures, researchers at Weill Cornell Medicine have developed a way to grow organoid structures that mimic actual patients’ tumors, and allow our researchers to study how different cancers develop, change, and might respond to various drug therapies.
XERMELO MOA
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XVIVO partnered with Lexicon Pharmaceuticals to create a series of high end medical animations that provide an overview of carcinoid syndrome diarrhea (CSD). The program illustrates how XERMELO, through the inhibition of TPH, turns down the overproduction of serotonin within neuroendocrine tumor cells, helping patients gain control over carcinoid syndrome.
NANOT BIOANIMATION 2020
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Jordan Maire
Pulsatile blood flow takes you on a ride as a red blood cell through the circulatory system in the Nanot animation. We begin the animation with the role of natural killer (or NK) cells as a part of the innate immune system that defends against cell malfunction as well as foreign particles (like bacteria or viruses). NK cells have a mechanism to identify and destroy damaged or diseased cells.
COBRA PLATFORM MOA
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admin
Maverick Therapeutics collaborated with the XVIVO team to create a scientific animation that brought to life the highly complex and novel mechanism of action behind Maverick’s pioneering approach to T cell-engaging immunotherapies. A product of brilliant protein engineering, Maverick’s COBRA™ therapeutic platform generates conditionally active bispecific T cell engagers designed to eliminate solid tumors.
BRAIN SHUTTLE
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admin
The blood-brain barrier (BBB) is a highly selective membrane system that prevents unwanted passage of molecules into the brain extracellular fluid. Consequently, the BBB also significantly hinders the effectiveness of drugs used to treat a number of neurological disorders. Roche has engineered a protein module that can greatly enhance the passage of therapeutic agents across the blood-brain barrier. This 3D medical animation depicts the mechanism by which the “Brain Shuttle” module operates.
GLUTAMATE MODULATION
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admin
Glutamate is the most abundant excitatory neurotransmitter in the brain. Release of glutamate is essential for normal function of neurons, but the levels of this neurotransmitter must be tightly regulated to avoid toxic effects on neurons. XVIVO partnered with Biohaven to animate the glutamate story.