PALOVAROTENE MOA

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Fibrodysplasia ossificans progressiva, or FOP, is an extremely rare and debilitating disorder, in which bone tissue gradually replaces soft tissue throughout the body, extending the skeleton and “freezing” patients into position.

A detailed, close-up view of muscle fibers and cells, showcasing red and pink strands with spherical cells interspersed throughout. The image highlights the intricate texture and structure of muscle tissue, offering insights into Palovarotenes potential MOA in influencing cellular architecture.

FOP is an autosomal dominant disorder, and is believed to be caused by a mutation in the ACVR1 gene, which results in constitutively active BMP signaling.

Clementia Pharmaceuticals is investigating Palovarotene as a RAR-gamma agonist capable of inhibiting BMP signaling, which may prevent heterotopic ossification and slow the progression of this devastating disease.

This illustration of a biological process features a cell membrane brimming with various proteins, including details of the PALOVAROTENE MOA. Large, colorful molecules interact across the membrane amid smaller scattered particles, while vivid colors emphasize dynamic cellular activity.
A close-up visualization of complex protein structures in shades of purple, brown, and gold, perhaps unveiling the mechanism of action for palovarotene, all elegantly floating in a dark, abstract space. Small particles are dispersed throughout, suggesting a microscopic, biological scene.

Learn more about this animation in our blog, Rare Diseases Deserves a Voice

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