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RNA SPINACH TECHNOLOGY

XVIVO teamed up with Lucerna Technologies to showcase their fluorescent labeling platform called Spinach. Fluorescent labels are used regularly in research settings to bind to proteins and help observe biological processes in action. Spinach was created to mimic a commonly used label, green fluorescent protein, but to bind to RNA instead of proteins, enabling an easier way of imaging RNA processes in live cells compared to existing methods.

XVIVO’s Augmented and Virtual Reality Celluverse Experience

Step into the future of scientific exploration with XVIVO’s AR and VR experience designed for the Oculus Quest 3. Our beautiful, immersive, and often snarky program takes you inside the intricate world of intracellular signaling, bringing medical concepts to life like never before. 

USING GENETIC ENGINEERING TO MAKE VACCINES

In the particular case shown in this animation, the plasmid is making the surface protein from the hepatitis B virus. Scientific detail is retained in the animation through the production of messenger RNA and translation by the ribosome to generate the structure of the hepatitis B surface protein.

HOW DOES HEPATITIS B COMBAT THE IMMUNE SYSTEM?

The 8th animation in a series of 9 on the immune system and vaccines shows a swarm of hepatitis B proteins that vastly outnumber the neutralizing antibodies, and the viral particle making its escape to infect another cell

THE ADAPTIVE IMMUNE SYSTEM

In conjunction with the innate immune system, the adaptive immune system protects our body from infection and damage from foreign bodies (like bacteria and viruses). The adaptive immune system provides our body with a targeted defense by producing antibodies, which are made-to-order proteins against a particular feature of a particular invader.

Illustrating the Unconventional: PROTAC™ Technology for Disease Therapy

XVIVO, in collaboration with Wyant Simboli and their client, Arvinas Inc., helped communicate the unconventional mechanism of action for a new class of drugs that engage the body’s own protein disposal system to target cancers and other difficult-to-treat diseases. PROTAC™ PLATFORM Arvinas’ approach is to tag a protein implicated in a disease with their proprietary Proteolysis-Targeting Chimera, …

How Do Cilia and Flagella Move?

The XVIVO team is proud of a recent project in collaboration with Dr. Daniela Nicastro , Associate Professor at the University of Texas Southwestern Medical Center. Dr. Nicastro and her research colleagues had completed some complex and ground-breaking research into how cilia and flagella generate their whip-like motion, and they asked XVIVO to help them visualize the …

THE INNER LIFE OF THE CELL: PROTEIN PACKING

Harvard University and XVIVO come together again to add to the growing series of scientific animations for BioVisions – Harvard’s multimedia lab in the department of Molecular and Cellular Biology. Protein Packing strives to more accurately depict the molecular chaos in each and every cell, with proteins jittering around in what may seem like random motion. Proteins occupy roughly …

CHRONIC IDIOPATHIC CONSTIPATION

These clips come from a project we developed that discuss the mechanisms of disease of Chronic Idiopathic Constipation (CIC) and Irritable Bowel Syndrome with Constipation (IBS-C). This medical animation depicts the micro-anatomy of the bowel from the level of bowel surface microvilli, down to the traffic of ions and proteins across specialized tight junctions that …