Mitochondria
Mitochondria are famous for being the power houses of the cell. While they are known most for manufacturing energy, they are also involved in cell growth and cell death.
Search Results for Cell
Kinesin Motor Protein with Vesicle
This iconic illustration from Harvard’s Inner Life of a Cell depicts a kinesin motor protein.
Roxadustat
Anemia often manifests as chronic kidney disease progresses. Roxadustat is a drug engineered to inhibit HIF prolyl-hydroxylase. This allows the HIF complex to form which upregulates certain genes leading to an increased production of hemoglobin and red blood cells. Thus treating CKD related anemia.
CLATHRIN UNCOATING
This illustration from Harvard’s Inner Life of a Cell: Protein Packing depicts clathrin proteins that are involved in building coats for small vesicles. In this image, the clathrin proteins are unraveling to release the vesicle and its contents.
LIFE CYCLE OF INFLUENZA A – Narrated by: Forest Whitaker
This science animation was developed for Zirus, a biopharmaceutical company that was working on the development of a new class of antivirals. This video excerpt, taken from a larger program developed for Zirus, uses the H1N1 influenza-A virus to example the mechanism of action a virus takes to infect a host cell.
FROM MELANOCYTE TO MELANOMA
Working with MELA Sciences, we designed this medical animation to help doctors and their patients understand the underlying cause of melanoma. Focusing on the cellular biology of melanocytes and keratinocytes, this video explains the process by which melanoma develops and the importance of early detection.
APOPTOSIS AND BCL-2
ABT-199/GDC-0199 is a small molecule drug in co-development by Abbvie and Genentech for the selective inhibition of BCL-2, a key regulator of cellular apoptosis. BCL-2, part of the larger BCL-2 family, is responsible for the sequestration of pro-apoptotic proteins along the mitochondrial membrane. Displacement of these proteins from BCL-2 in cancerous cells may prime these cells for apoptosis.
GLEEVEC (IMATINIB) MOA
Kit is a receptor tyrosine kinase that activates of a number of pathways that direct cell proliferation, survival, and apoptosis. Mutations in Kit that result in constitutive oligomerization in the absence of ligand can drive continuous oncogenic signaling.
XERMELO MOA
XVIVO partnered with Lexicon Pharmaceuticals to create a series of high end medical animations that provide an overview of carcinoid syndrome diarrhea (CSD). The program illustrates how XERMELO, through the inhibition of TPH, turns down the overproduction of serotonin within neuroendocrine tumor cells, helping patients gain control over carcinoid syndrome.
NANOT BIOANIMATION 2020
Pulsatile blood flow takes you on a ride as a red blood cell through the circulatory system in the Nanot animation. We begin the animation with the role of natural killer (or NK) cells as a part of the innate immune system that defends against cell malfunction as well as foreign particles (like bacteria or viruses). NK cells have a mechanism to identify and destroy damaged or diseased cells.