An illustration for Mirati Therapeutics depicts the molecular basis of a healthy state, a diseased state, and how their investigational agent MRTX123, targets the diseased state. As a static image, this illustration is layered with visual and scientific detail that hooks the viewer initially and makes them linger to fully absorb the complexity of the …
Over time the skin begins to lose its ability to fully repair itself. Both the cutaneous cells as well as the extracellular matrix show changes in structure and function which result in a loss of elasticity. Accumulation of these changes is visible in the wrinkling of the skin.
Cancers are marked by an elevated rate of cell replication; this is often a result of an abnormal presentation of particular cell signaling pathways. Some treatments for cancer modulate these overactive pathways by targeting certain pathway essential proteins, through inhibition of function, post-transcription modifications, gene therapy and epigenetic modulation.
The drug showcased in this illustration is an Agonist Redirected Checkpoint (ARC) construct. It simultaneously blocks the immune suppressive ‘Don’t Eat Me’ signal from the tumor cell, while initiating the adaptive immune response through the antigen presenting cell. This specific ARC construct belongs to a larger group of modular constructs, each consisting of different combinations …
This illustration was developed to showcase two novel Kleo Pharmaceuticals technologies. Antibody Recruiting Molecules (ARM™s) are bispecific molecules which assist in the recruitment of endogenous antibodies to target diseased cells to initiate immune destruction. Monoclonal Antibody Therapy Enhancers (MATE™s) facilitate the chemical engineering of existing antibodies, which are then administered to clients to enhance the …
This illustration is an overview of the key molecules involved in breast cell proliferation and cancer. The restriction point represents a key moment in the cell cycle where cell proliferation can be terminated.
The KRAS signaling pathway controls cell proliferation, survival, and growth. When the KRAS gene coding for the K-Ras protein mutates, abnormal activation of this pathway can result in uncontrolled cell proliferation, resulting in tumor growth. KRAS, an oncogene, is therefore a valuable target for research and drug development.
Colonic bacteria can be anti-inflammatory or pro-inflammatory. This illustration was made to detail the anti-inflammatory signaling and cellular interactions that can mitigate colorectal carcinogenesis.
As a method of replication viruses can introduce their genetic material into the target cell’s nucleus. Gene therapy treatments such as Adstiladrin exploits this mechanism to deliver genes into cells. These genes code for functional proteins necessary to combat non-muscle-invasive bladder cancer.
The bone marrow produces blood cells, which are exported to the rest of the body through the vasculature present in the bone marrow.