The drug showcased in this illustration is an Agonist Redirected Checkpoint (ARC) construct. It simultaneously blocks the immune suppressive ‘Don’t Eat Me’ signal from the tumor cell, while initiating the adaptive immune response through the antigen presenting cell. This specific ARC construct belongs to a larger group of modular constructs, each consisting of different combinations of checkpoint molecules bound to the Fc region to target different pathways involved in cancer.
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